Finally, vitamin C increases the bioavailability of iron from foods by enhancing intestinal absorption of non-heme iron (see the article on Iron) (21). Current evidence from controlled clinical trials indicates that intravenous vitamin C is generally safe and well tolerated in cancer patients. Levine M, Rumsey SC, Daruwala R, Park JB, Wang Y. 2006;27(11):2250-2257. Protagonist and main lead go on a journey of solving seemingly random mysteries as they travel to their destination, all throughout which they discover more about each-other and themselves. In vitro experiments performed using 11 different cancer cell lines demonstrated that sensitivity to vitamin C correlated with the expression of catalase, an enzyme involved in the decomposition of hydrogen peroxide (172). 1976;73(10):3685-3689. Levy AP, Friedenberg P, Lotan R, et al. (PubMed), 107. A third placebo-controlled trial in mildly cognitively impaired older adults (ages, 60-75 years) found that one-year supplementation with vitamin C (400 mg/day) and vitamin E (300 mg/day) improved antioxidant blood capacity but had no effect on MMSE scores (106). (PubMed), 159. (PubMed), 123. Roswall N, Olsen A, Christensen J, Dragsted LO, Overvad K, Tjonneland A. Micronutrient intake and risk of urothelial carcinoma in a prospective Danish cohort. Weinstein M, Babyn P, Zlotkin S. An orange a day keeps the doctor away: scurvy in the year 2000. The recommended intake for smokers is 35 mg/day higher than for nonsmokers, because smokers are under increased oxidative stress from the toxins in cigarette smoke and generally have lower blood concentrations of vitamin C (36). Although trials do not currently support the use of high-dose supplementation with vitamin C in cataract prevention, there is a consistent inverse association observed between high daily intake of fruit and/or vegetables (>5 servings/day) and risk of cataract (113). Nutrients. (PubMed), 192. Ann Thorac Surg. 10. Vitamin C intake and serum uric acid concentration in men. Alzheimer's Association. In the second prospective cohort study, the Diet, Cancer and Health Study, 55,543 Danish adults (ages 50-64 years) were questioned at baseline about their lifestyle, diet, and supplement use during the previous 12 months (125). Overall, an inverse association between fruit and vegetable intake and risk of NHL was observed. Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbic acid in patients with advanced cancer. If not can anyone tell me all of them? 2004;80(6):1508-1520. Many times I needed to find the column number associated with a column letter in order to use it in Excel Macro. 6 Lovers; Add to list. Oregon State University, Updated in November 2002 by:   Such symptoms appear to be related to the weakening of blood vessels, connective tissue, and bone, which all contain collagen. Conde-Agudelo A, Althabe F, Belizan JM, Kafury-Goeta AC. Another meta-analysis of 40 randomized controlled trials in 276,820 women found no effect of vitamin C, alone or combined with vitamin E or multivitamins, when supplemented during pregnancy (starting prior to 20 weeks’ gestation), on the risks of overall fetal loss, miscarriage, stillbirth, and congenital malformation (89). The following recommendations will be grouped into sets of three with similar themes (or at least that’s what I’ll try to do, but that’s not always possible). The title explain itself.This is for those who love to cry over fictional character because they have nothing better to do. 19 hours ago:heavy_check_mark: LINK :heavy_check_mark: - My Bromance 2: 5 Years Later - Episode 07 ╔┓┏╦━━╦┓╔┓╔━━╗ ║┗┛║┗━╣┃║┃ Prospective cohort studies can examine the incidence of a specific disease in relation to vitamin C intake or body status in a cohort of participants who are followed over time. There is a need for larger, longer-duration phase II clinical trials that test the efficacy of intravenous vitamin C in disease progression and overall survival (176). 2012;130(1):147-158. Chen GC, Lu DB, Pang Z, Liu QF. Current evidence of the efficacy of intravenous vitamin C in cancer patients is limited to observational studies, uncontrolled interventions, and case reports (174, 175). Linus Pauling Institute  The national study identified smokers and those of lower socioeconomic status to both be at higher risk for vitamin C deficiency (36). In the Vitamins and Lifestyle Study, 55,543 men and women (ages 50-76 years) were questioned at baseline on their use of dietary supplements during the previous 10 years (124). 2005;4:5. Polymeropoulos E, Bagos P, Papadimitriou M, Rizos I, Patsouris E, Tauoumpoulis I. Vitamin C for the prevention of postoperative atrial fibrillation after cardiac surgery: a meta-analysis. Final Thoughts. Two large prospective cohort studies assessed the relationship between dietary and supplemental vitamin C intakes and mortality. In another randomized, double-blind, controlled trial in 28 critically ill patients with septic shock, infusion of 25 mg of vitamin C per kg every six hours for 72 hours significantly limited the requirement to vasopressor norepinephrine — decreasing both the dose and duration of treatment — and dramatically improved the 28-day survival rate (155). Recommendations BL With animal MC. The effect of vitamin C supplementation, in combination with other antioxidants, on CSF biomarkers and cognitive function has been examined in only a few trials involving AD patients. 2013;32(12):1508-1517. Pauling L. The immune system. Higher SVCT-2 levels were associated with enhanced sensitivity to vitamin C in nine different breast cancer cell lines. Amelioration of persistent left ventricular function impairment through increased plasma ascorbate levels following myocardial infarction. Advanced List Search . Although liposomal encapsulation could increase vitamin C bioavailability, plasma vitamin C concentrations were much lower than those achieved with intravenous vitamin C administration (190). Hankey GJ. Arthritis Res Ther. Baltimore, MD: Lippincott Williams & Wilkins; 2014:416-426. The results of this study also indicated that supplemental vitamin C may be helpful in the prevention of gout (119). Acta Pathol Microbiol Scand B. No association between dietary or supplemental intake of vitamin C and mortality was found after approximately 14 years of follow-up. no kiss or anything. 177. Semin Arthritis Rheum. Washington, D.C.: National Academy Press; 2000:95-185. J Am Coll Nutr. (PubMed), 208. (PubMed), 116. The role of increased oxidative stress in the occurrence of vascular complications in subjects with diabetes has led to hypothesis that higher intakes of antioxidant nutrients could help lower the risk of CVD in diabetic subjects (144). 16. One small placebo-controlled, cross-over trial in 11 men showed that the oral administration of 4 g of vitamin C resulted in a greater vitamin C concentration in plasma over a four-hour period when vitamin C was encapsulated in liposomes compared to unencapsulated vitamin C (190). Caramel Honey. Cancer Epidemiol Biomarkers Prev. Myint PK, Luben RN, Wareham NJ, Khaw KT. Arthritis Rheum. The Shibata study. More recent prospective cohort studies have reported no association between dietary and/or supplemental vitamin C intake and breast cancer (67-69). 2011;40(6):483-500. A recent randomized controlled trial assessed the effect of vitamin C and vitamin E administration on reperfusion damage in patients who experienced acute myocardial infarction and underwent coronary angioplasty (see below) (132). Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials. Cardiovasc Res. Ganediwala, an … Does vitamin C act as a pro-oxidant under physiological conditions? A 2017 review of eight published randomized controlled trials found inconsistent results from seven trials reporting on the effect of vitamin C supplementation on serum cholesterol and triglycerides, established risk factors for cardiovascular disease (52). Int J Cancer. Arthritis Care Res (Hoboken). J Am Heart Assoc. Controversy surrounding the efficacy of vitamin C in cancer treatment ensued, leading to the recognition that the route of vitamin C administration is critical (22, 159). Interestingly, there was no relationship between diet score and risk of hypertension in those with the lowest plasma vitamin C, and plasma vitamin C was positively associated with risk of hypertension in those with low diet scores (44). Antioxidant effects of vitamins in type 2 diabetes: a meta-analysis of randomized controlled trials. (PubMed), 166. Ames, Iowa: Wiley-Blackwell; 2012:248-260. In this list, there will be a variety of novels that I have read throughout my journey. It is widely thought by the general public that vitamin C boosts immune function, yet human studies published to date are conflicting. (PubMed), 204. Eur J Cancer Prev. Am J Clin Nutr. Anger meter getting high up into the clouds inducing novels. Natural and synthetic L-ascorbic acid are chemically identical and there are no known differences regarding biological activities or bioavailability (186). (PubMed), 131. 2006;114(3):350-354. Alberts B, Bray D, Lewis J, Raff M. Differentiated cells and the maintenance of tissues. (PubMed), 77. New York: Macel Dekker, Inc.; 1997:309-322. hugs or holding hands the most you can see. with emoji, so you'll see which. However, no difference in the infarct size between antioxidant vitamin treatment and placebo was seen (138). but due to my own taste would. 1986;6:365-406. A few observational studies in cancer patients undergoing chemotherapy and/or radiotherapy reported that complementary intravenous vitamin C treatment was associated with a reduction in treatment-associated side effects and an improved quality of life (171). J Enzyme Inhib Med Chem. These observations need to be confirmed in larger, well-designed trials. (PubMed), 153. Arch Ophthalmol. J Emerg Med. 2013;65(6):1636-1642. 2010;91(2):487-493. (PubMed), 82. I’ve read and watched many more titles than these, but grouping them together sometimes proves to be difficult, so I’m always looking for new titles. (PubMed), 102. JAMA Intern Med. Each of the cohort studies used self-administered food frequency questionnaires at baseline to assess vitamin C intake. Linus Pauling Institute Levy R, Shriker O, Porath A, Riesenberg K, Schlaeffer F. Vitamin C for the treatment of recurrent furunculosis in patients with impaired neutrophil functions. it's usually shounen or shoujo. Linus Pauling Institute   (PubMed), 148. Breast Cancer Res Treat. (PubMed), 171. Conversely, there are case reports suggesting that supplemental vitamin C may lower blood concentrations of some medications, such as fluphenazine (the antipsychotic drug, Prolixin) and indinavir (the antiretroviral drug, Crixivan) (200). A 2013 meta-analysis of 53 placebo-controlled trials evaluated the effect of vitamin C supplementation on the incidence, duration, or severity of the common cold when taken as a continuous daily supplement (43 trials) or as therapy upon onset of cold symptoms (10 trials) (178). Bertoia M, Albanes D, Mayne ST, Mannisto S, Virtamo J, Wright ME. Myocardial reperfusion injury: Reperfusion injury refers to tissue damage occurring at the time of blood flow restoration (reperfusion) following transient ischemia. Vitamin-C as anti-Helicobacter pylori agent: More prophylactic than curative- Critical review. No hot bed scenes but boy this manhwa kept me so hot just with the plot twists. 2016;5(2):94-100. (PubMed), 13. Additional studies have reported that vitamin C enhances the chemotactic and microbial killing capacities of neutrophils and stimulates the proliferation and differentiation of B- and T-lymphocytes (reviewed in 18). 107 people. Mostly comedy, bc that's what I read usually. You may not copy, modify, distribute, display, transmit, perform, publish or sell any of the copyrightable material on this website. (PubMed), 23. (National Academy Press), 36. Phase I clinical trial of i.v. 2001;98(17):9842-9846. A prospective study that followed a cohort of 46,994 men for 20 years found that total daily vitamin C intake was inversely associated with incidence of gout, with higher intakes being associated with greater risk reductions (119). 2017;21(1):300. Giana Angelo, Ph.D.  Once plasma vitamin C concentrations reach saturation, additional vitamin C is largely excreted in the urine. Padayatty SJ, Sun H, Wang Y, et al. properties.risk risk; The potential risk of not implementing the recommendation. 178. Each show will be marked. 2012;66(5):561-568. ascorbic acid in advanced malignancy. Krajewska B, Brindell M. Urease activity and L-ascorbic acid. 2011;34(1):108-114. (PubMed), 90. (PubMed), 189. (PubMed), 75. Vitamin C treatment substantially reduced the incidence of periprocedural myocardial injury, as assessed by a reduction in the concentrations of two markers of myocardial injury, namely creatine kinase and troponin-I (131). Hints: [New]- New movie/drama/episode ⭐ - Recomm... BL Dramas . Curr Opin Crit Care. Good quality long-term trials are needed to examine whether the anti-hypertensive effect of vitamin C is sustained over time and eventually results in a reduced risk of cardiovascular events. Ascorbic Acid: Biochemistry and Biomedical Cell Biology. An intervention trial in 75 adult male smokers found that supplementation with 1,000 mg/day of vitamin C resulted in significantly lower blood lead concentration over a four-week treatment period compared to placebo (184). (PubMed), 54. (PubMed), 27. 2018;9:1182. The amount of vitamin C required to help prevent chronic disease is higher than the amount required for prevention of scurvy. For instance, in a study of 747 older men, blood lead concentration was significantly higher in those who reported total dietary vitamin C intakes averaging less than 109 mg/day compared to those with higher vitamin C intakes (181). The effect of ascorbic acid ingestion on the biochemical and physicochemical risk factors associated with calcium oxalate kidney stone formation. Similar results have been reported in septic patients given intravenous vitamin C (1.5 g/6 h), hydrocortisone (50 mg/6 h), and thiamin (200 mg/12 h) until hospital discharge. Effect of high dose vitamin C on urinary oxalate levels. In the National Institutes of Health (NIH)-American Association of Retired Persons (AARP) Diet and Health study that included 232,007 participants, the use of vitamin C supplements for at least seven times a week was associated with a 9% lower risk of developing type 2 diabetes mellitus compared to non-supplement use (83). Because maximizing blood concentrations of vitamin C may be important in protecting against oxidative damage to cells and biological molecules, a vitamin C intake of at least 400 mg daily might benefit older adults who are at higher risk for chronic diseases caused, in part, by oxidative damage, such as heart disease, stroke, certain cancers, and cataract. In addition, vitamin C may bind aluminum in the gut and increase the absorption of aluminum-containing compounds (e.g., aluminum-containing antacids, aluminum-containing phosphate binders). Hemila H, Suonsyrja T. Vitamin C for preventing atrial fibrillation in high risk patients: a systematic review and meta-analysis. (PubMed), 10. (PubMed), 196. (PubMed), 152. Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross-sectional associations with insulin resistance and glycaemia in 9-10 year-old children. Read BL Manga Recommendations List created from the story BL Novel Recommendations 60+ 《Ongoing》 by ShizunLi (Shizun) with 2,084 reads. 1996;173(6):1502-1505. We saved what we feel to believe is truly the best romance manhwa out there for last for our Top 10 Romance Manhwa recommendation list. The kinda novels to read when you have a bad day and just want some love and fluff. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. However, leukocyte vitamin C concentration does not accurately reflect vitamin C in several tissues and may specifically underestimate vitamin C uptake into skeletal muscle (26). (PubMed), 55. (PubMed), 83. Sodium ascorbate and calcium ascorbate are the most common forms, although a number of other mineral ascorbates are available. Natural resistance to ascorbic acid induced oxidative stress is mainly mediated by catalase activity in human cancer cells and catalase-silencing sensitizes to oxidative stress. A 2015 meta-analysis of 29 randomized controlled trials found that administration of vitamin C during pregnancy, alone or in combination with a few other supplements, failed to reduce the risks of stillbirth, perinatal death, intrauterine growth restriction, preterm birth, premature rupture of membranes, and preeclampsia (88). Authors' perspective: What is the optimum intake of vitamin C in humans? 2014(10):Cd010156. Regular supplementation with vitamin C (0.25 to 2 g/day) did not reduce the incidence of colds in the general population (23 trials); however, in participants undergoing heavy physical stress (e.g., marathon runners, skiers, or soldiers in subarctic conditions), vitamin C supplementation halved the incidence of colds (5 trials). Adjuvant effect of vitamin C on omeprazole-amoxicillin-clarithromycin triple therapy for Helicobacter pylori eradication. J Transl Med. Specifically, plasma vitamin C ranged from approximately 23 to 70 μmol/L in men and 33 to 82 μmol/L in women; across this range, every 20 μmol/L increase in plasma vitamin C was associated with a 9% reduction in risk of heart failure. Tsugane S, Sasazuki S. Diet and the risk of gastric cancer: review of epidemiological evidence. Association of vitamin C with the risk of age-related cataract: a meta-analysis. (PubMed), 67. Int J Surg. Vitamin C supplementation for pregnant smoking women and pulmonary function in their newborn infants: a randomized clinical trial. Mann EA, Baun MM, Meininger JC, Wade CE. In a cross-sectional study conducted in 4,576 African Americans, the odds of having hyperuricemia was associated with dietary intakes high in fructose, low in vitamin C, or with high fructose-to-vitamin C ratios (118). Association between plasma vitamin C concentrations and blood pressure in the European prospective investigation into cancer-Norfolk population-based study. The marking is. Jane Higdon, Ph.D.  Reiss GR, Werness PG, Zollman PE, Brubaker RF. In contrast, observational studies reported lower plasma vitamin C concentrations in AD patients compared to cognitively healthy subjects (101) and found better cognitive function or lower risk of cognitive impairment with higher plasma vitamin C (100). After five years of follow-up, vitamin C supplement use was associated with a small decreased risk of total mortality, although no association was found with cardiovascular disease- or cancer-specific mortality. 1997;15(6):795-801. Am J Clin Nutr. Plasma concentrations of ascorbate reach steady-state at concentrations between 60 and 80 micromoles/L (μmol/L). Int J Cancer. Lykkesfeldt J, Poulsen HE. Vitamin C, also known as L-ascorbic acid, is a water-soluble, There is some evidence to suggest that vitamin C may be a useful, There are insufficient data to suggest a link between vitamin C status and the risk of developing a given type of. 2008;35(9):1853-1858. Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts. What You Need to Know: Given is a big deal … The novels here remains the same genre as the others' and only includes two categories: Your typical "reincarnation-into" works, where the female protagonist enter the world of novels, games, or simply an unknown another world. Share. Effects of a novel ascorbate-based protocol on infarct size and ventricle function in acute myocardial infarction patients undergoing percutaneous coronary angioplasty. Although a primary source of dietary vitamin C, consumption of fruit and vegetables — assessed by food frequency questionnaire — was not found to be associated with a lower risk of congestive heart failure (49). Additionally, dietary, but not supplemental, intake of vitamin C and other antioxidant nutrients (carotenoids, proanthocyanidins, and manganese) was inversely associated with NHL risk. Complete list of bl anime, and watch online. Buy now. Hepatogastroenterology. 1996;155(6):1847-1851. Plasma ascorbic acid, a priori diet quality score, and incident hypertension: a prospective cohort study. Linus Pauling Institute Recommendation. A 2013 systematic review identified 11 randomized controlled studies that evaluated the effect of vitamin C on asthma (eight trials) or exercise-induced bronchoconstriction (three trials) (180). Cochrane Database Syst Rev. There is some evidence, though controversial, that vitamin C interacts with anticoagulant medications like warfarin (Coumadin). Leuk Lymphoma. 2008;19(11):1969-1974. 2014;100(3):915-923. Oxidative stress, neuroinflammation, β-amyloid plaque deposition, Tau protein-forming tangles, and neuronal cell death in the brain of subjects affected by AD have been associated with cognitive decline and memory loss. (PubMed), 154. By pooling data from 13 prospective cohort studies comprising 676,141 participants, it was determined that dietary intake of vitamin C was not associated with colon cancer, while total intake of vitamin C (i.e., from food and supplements) was associated with a 19% reduced risk of colon cancer (79). Ischemic stroke occurs when an obstruction within a blood vessel blocks blood flow to the brain. The potential effect of antioxidants during chemotherapy is not well understood, yet only likely to be an issue if a specific chemotherapeutic agent acts through an oxidative mechanism, which is uncommon (171). Many prospective cohort studies have examined the relationship between vitamin C intake from diet and supplements and CHD risk, the results of which have been pooled and analyzed in two separate analyses (46, 47). Cochrane Database Syst Rev. Englard S, Seifter S. The biochemical functions of ascorbic acid. Lagowska-Lenard M, Stelmasiak Z, Bartosik-Psujek H. Influence of vitamin C on markers of oxidative stress in the earliest period of ischemic stroke. (PubMed), 7  Panush RS, Delafuente JC, Katz P, Johnson J. Modulation of certain immunologic responses by vitamin C. III. I'm totally open to new recommendations, this is becoming a favorite sub-genre/thing of mine. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. 1999;10(4):840-845. Vitamin C, through its antioxidant functions, has been shown to protect leukocytes from self-inflicted oxidative damage (14). Redox Rep. 2016;21(2):75-83. Recommendations Make a recommendation. Int J Vitam Nutr Res. One 12-month randomized placebo-controlled trial in 456 participants with type 2 diabetes treated with metformin examined the effect of vitamin C (500 mg/day) or acetylsalicylic acid (aspirin; 100 mg/day) on risk factors for diabetes-related complications such as CVD (147). Large doses of vitamin C may block the action of warfarin and thus lower its effectiveness. J Urol. SOTUS SOTUS S (Thai sequel ) of SOTUS. Freeman; 1970. 1983;29(5):305-310. Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo. Arch Intern Med. Bowman GL, Dodge H, Frei B, et al. A three-year randomized controlled trial in 160 patients with documented coronary heart disease and low blood HDL concentrations found that a combination of simvastatin (Zocor) and niacin increased HDL concentration, inhibited the progression of coronary artery stenosis (narrowing), and decreased the frequency of cardiovascular events, such as myocardial infarction and stroke (202). (PubMed). 2017;3:Cd011114. ( 2 PT 1 ):397-401 approximately 14 years of follow-up read when you have come to plasma. Of all BL anime on crunchyroll the manhwas that I have n't gotten around to reading is. Individuals predisposed to oxalate kidney stone formation with vitamin C ester, '' which should not be used in of. Control trial vasoconstriction and coagulation abnormalities cardiovascular complication ; a summary of the book ) C. 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